Saturday, October 19, 2019
Banana as a Natural Superdisintegrant
Banana as a Natural Superdisintegrant The objective of the study was to evaluate banana powder as a superdisintegrant for the formulation of oral disintegrating tablets and to compare the results with commonly used superdisintegrants like croscarmellose sodium, pre gelatinised starch and sodium starch glycolate. Oral disintegrating tablets containing Domperidone as the model drug were formulated using five different concentrations of each superdisintegrant (2%, 4%, 6%, 8% & 10%) and compressed by direct compression. The formulations were subjected to various evaluation studies such as wetting time, water absorption ratio, disintegration time and in-vitro dissolution. The results showed that the disintegration time and drug release of the formulation containing banana powder (6%) was comparable to other super disintegrants. The IR spectrum analysis demonstrated that banana powder was compatible with the drug. These results suggest that banana powder can be used effectively as a superdisintegrant in orally disintegrating tablet formulations. Banana, is a natural product which is available in plenty, economically affordable and has its own nutritional value. It can be used as a potential additive in the formulation of oro -dispersible tablets. Keyword: orodispersible tablets, superdisintegrants, disintegration time, natural excipients. INTRODUCTION The tablet is the widely used dosage form because of its convenience in terms of self-administration, compactness, and ease in manufacturing. For the past one decade, there has been a demand for more patient-friendly and compliant dosage forms. As a result, the development of new technologies has been increasing annually. Since the cost for development new drug molecule is very high, efforts are now being made by pharmaceutical companies to focus on the development of new drug dosage forms for existing drugs with more safety and efficacy together with reduced dosing frequency, and the production of more cost-effective dosage forms. However, geriatric and p ediatric patients were having difficulty in swallowing conventional tablets, which leads to poor patient compliance. To overcome this problem, scientists have developed innovative drug delivery systems known as Ã¢â¬Å"melt in mouthÃ¢â¬ or Ã¢â¬Å"mouth dissolve (MD)Ã¢â¬ or sometimes Ã¢â¬Å"dispersibleÃ¢â¬ tablets. These are novel types of tablets that disintegrate /disperse in saliva. Their characteristic advantages such as administration without water, lead to suitability for the geriatric and pediatric patients. They are also suitable for the bedridden patients, and patients who do not have easy access to water. The advantages, in terms of patient compliance, rapid onset of action, increased bioavailability (in some instances) and comparable stability to conventional tablets make these tablets popular as a dosage form of choice particularly in these populations. Domperidone maleate is a widely used anti-emetic drug, acting by inhibition of the dopaminergic receptor. Domper idone maleate does not cross the blood brain barrier. Domperidone maleate is also effective in gastro paresis, pediatrics gastro esophageal reflux (infant vomiting). Domperidone maleate after oral dosing undergoes extensive gastric and hepatic first pass metabolism resulting in low bioavailability (15%) which therefore, may not minimize the rate of vomiting. In context of the above principles, a strong need was recognized for the development of mouth dissolving tablets of Domperidone maleate to improve its bioavailability for relief on nausea and vomiting. In mouth dissolving tablets, disintegrants plays a major role. AÃ disintegrantÃ is a substance in a tablet formulation that enables the tablet to break up into smaller fragments upon contact with gastrointestinal fluids. Such a rapid rupture of the tablet matrix increases the surface area of the tablet particles, thereby increasing the rate of absorption of the active ingredient and decreasing the onset of time to therapeutic effect. A new disintegrant class has emerged during the recent past known as the Superdisintegrant. Superdisintegrants improve disintegrant efficiency resulting in decreased use levels, typically 1-10% by weight relative to total weight of tablet when compared to traditional disintegrants.